DNA methylation changes can be used as a biomarker of aging because its abnormal age-dependent changes are a potential cause of the aging process and the development of age-related diseases. A number of interventions have been demonstrated to prevent age-related diseases and extend lifespan, including dietary, pharmacological, and genetic, and most of the changes are associated with age-related DNA methylation changes.
The key service we provide is the development and use of DNA methylation clocks in animal models and their application to test longevity interventions.
- DNA methylation clock development. We use DNA methylation techniques to develop specialized age prediction clocks for different animal models, allowing us to assess changes in DNA methylation age of experimental subjects with interventions.
- Longevity interventions evaluation. We characterize changes in biological age in experimental and control groups of animal models under different intervention conditions and assess the effects of dietary, pharmacological, and genetic interventions on mean life expectancy.